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Always take Tramadol capsules exactly as your doctor has told you. To be taken for as long as prescribed by your doctor. See also Drug Interactions section. Tramadol has inhibitory actions on the 5-HT 2C receptor. Journal of Pain and Symptom Management. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Click here for US version. Tramadol / Ultram - Side Effects, Drug Interactions, And Natural Anti Inflammatory Alternatives