Order Amending Schedules I and III to the Controlled Drugs and Substances Act (AH, MT, W and Lefetamine), SOR/ “This Order comes into force .. Proposal regarding the regulation of tramadol under the Controlled Drugs and Substances Act (CDSA) and its Regulations. Health Canada summarizes. Aug 22, - Stephanie Younts, PharmD. Controlled Substance Update: Tramadol & Hydrocodone. Emmanuel Aniemeke, PharmD, UHS PGY1 Pharmacy Resident. Controlled substances are drugs, chemicals or immediate precursors that are classified into Schedules. I, II, III, IV, or V under the Controlled Substance Act. The Controlled Substances Act consists of 2 subchapters. Subchapter I defines Schedules I-V, lists chemicals used in the manufacture of controlled substances, and differentiates lawful and unlawful manufacturing, distribution, and possession of controlled substances, including possession of Schedule I drugs for personal U.S.C. sections created?: ?21 U.S.C. ch. 13 §